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Although definitions vary slightly across the literature, according to National Healthcare Safety Network (NHSN) criteria, a diagnosis of TACO requires the new onset or acute exacerbation of at least three of the following indicators within 6 h post-transfusion: respiratory distress, elevated brain natriuretic peptide (BNP or NT-pro-BNP) levels, increased central venous pressure (CVP), evidence of left heart failure, positive fluid balance, or pulmonary edema (52)

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