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Other metal chelating proteins also include transferrin and serum albumin, which play a key role in indirect antioxidant defence by sequestering free metal ions such as Fe 2 ⁺ and Cu 2 ⁺, preventing their participation in redox reactions that generate highly reactive species such as hydroxyl radical ( • OH) [22]

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Venous blood samples were obtained just before dosing and 20, 40 min, 1, 1.5, 2, 3, 4, 6, 8, 10 and 12 h after the administration of NAC 600 mg