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Further, HNE at micromolar concentrations has consistently been shown to up-regulate the expression of transcription factors such as Nuclear Factor-Kappa B (NF-kB) which regulate the expression of a variety of genes involved in cell proliferation and differentiation the activation of protein kinase C (PKC), mitogen activated protein kinase (MAPK) [44, 35, 36], and while at higher concentrations HNE has been shown to inhibit the formation of NF-kB [45]

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