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The use of antagonists or inhibitors that target specific elements of these signaling pathways—such as L-NAME, which inhibits NO synthase, and glibenclamide, which blocks K ATP channels—significantly diminishes the analgesic effectiveness of rutin

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[DOI] [PubMed] [Google Scholar] De Bleser PJ, Xu G, Rombouts K, Rogiers V, Geerts A

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