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Studies have also indicated interactions with opioid pathways — DSIP administration has been shown to modulate pain perception and has effects that can be partially blocked by opioid antagonists in some paradigms, suggesting opioidergic involvement in at least some of its actions

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The primary way SF protects BBB integrity appears to be through its activation of the Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2-related factor 2 (NRF2) pathway, since BBB integrity is rapidly compromised in the absence of Nrf2 transcriptional activity [32]