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10.1016/j.pt.2014.09.004 34 EmamiS.TavangarP.KeighobadiM

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The alteration in ATP would have a direct effect on SR-Ca 2+ and consequently on ECC, because any disturbance that causes even subtle changes in glycolytic flux could affect the release of SR-Ca 2+ and ECC [556,559,560], ultimately causing diastolic dysfunction (figure 4), an important hallmark of disease severity in patients with Chagas cardiomyopathy [562]