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Histamine intolerance results from reduced diamine oxidase (DAO) enzyme activity or excessive histamine accumulation, not IgE-mediated allergy Vitamin B12 supports histamine N-methyltransferase (HNMT) function through methylation reactions and maintains gut integrity where DAO is produced B12 deficiency may compromise intestinal health and methylation capacity, potentially worsening histamine metabolism in susceptible individuals No UK clinical guidelines recommend B12 supplementation specifically for histamine intolerance without confirmed deficiency Management requires low-histamine diet, addressing nutritional deficiencies, and GP assessment to exclude underlying conditions Seek immediate medical attention for anaphylaxis symptoms or severe reactions after eating fish Table of Contents What Is Histamine Intolerance and How Does It Develop
