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To confirm the role of TMAO in cellular inflammation, they injected 86 μmol of TMAO into Ldlr −/− mice, and half an hour later, the activation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase 1/2 (ERK1/2), and nuclear factor kappa-B p65 (NF-κB p65) cascade signaling were detected in aortic samples (46)

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