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Gene expression analysis showed that upon PTU treatment, tsh- β expression was increased in both WT and nrf2aΔ5 homozygous mutants, whereas slc5a5 expression increased in WT embryos compared with their nontreated siblings (Fig 2T and U), confirming the efficiency of PTU in inhibiting T.H

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Thus cells arrest their cell cycle in the G0/G1 and G2/M phases, leading to apoptosis in dividing cells (mainly tumor cells) (Hornick et al., 2008)