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PTM-regulating enzymes with multi-localization behavior may be targeted to a single location via different protein engineering approaches and fused with a PDB enzyme to identify potential compartment-specific substrates

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Early AD was reported to lead to a substantial increase in the quantity of 3-nitrotyrosine residues in proteins, including nitrosylated GDH, whose function is significantly diminished in some patients with early AD ( Conclusion GDH is an essential metabolic enzyme that links glutamate to numerous other metabolic pathways

Cancer Research