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Heme is a crucial part of the prosthetic groups of cytochromes in the electron transport chain (ETC), and disruption to the ETC results in disrupted mitochondrial homeostasis and increased ROS in endothelial cells [51]

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Fucoidan-treated rat serum modulates MCF-7 cells by upregulating E-cadherin and downregulating MMP-9, as it can significantly inhibit migration and invasion via attenuating EMT, while concurrently enhancing apoptosis (Lin et al., 2017)

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