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In the latter case, DDR1 (discoidin domain receptor tyrosine kinase 1) binds the PAR3/6 complex to localize RhoE to cell-cell junctions, antagonizing actomyosin contractility and promoting collective migration [59]

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This research was partially supported by the Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Supporting Innovative Drug Discovery and Life Science Research [BINDS]) from AMED under grant number JP17am0101001 (support number 1234), AMED-P-CREATE (JP19cm0106101 to M.Y.), JSPS KAKENHI 19H05649 (to M.Y.), and JSPS KAKENHI Grants-in-Aid for Early Career Scientists 19K16512 (to L.B.)