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In chronic liver damage, HSCs transdifferentiate from a “quiescent” to an “activated” state and are responsible for collagen deposition in the liver tissue, playing a key role in the fibrosis process

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The ginkgolides (1–100 μM in vitro or 50–100 mg/kg in vivo), bilobalide (25–100 μM in vitro or 10 mg/kg in vivo), and in some cases also the flavonoid fraction (25–100 μg/ml in vitro or 40–100 mg/kg in vivo) have been shown to contribute to the neuroprotective effect of EGb 761