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Scaling up production The industrial-scale manufacturing of nanomedicines presents unique challenges, requiring the careful selection of pharmaceutical-grade excipients, precise control over nanoparticle properties (size, charge, and structure), and rigorous quality assurance to ensure batch-to-batch consistency [114, 116]

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(iii) Methylmalonyl-CoA mutase also requires vitamin B12 as a cofactor and therefore a deficiency in vitamin B12 will result in the accumulation of methylmalonic acid as well

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