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A peptide is a short chain of amino acids .β He doesnβt think thereβs a real clear definition of what constitutes a peptide versus a protein Clearly, once youβre into the thousands of amino acids, youβre clearly talking about proteins Peter has read definitions that would suggest up to 60, up to 100 [amino acids], but the point is: itβs pretty small A relatively short number of amino acids strung together forms a peptide Sometimes itβs so short that itβs literally just a straight line of amino acids, and other times they form more complex structuresβthey form rings and things like that Peptides are things that the body naturally produces (there are many examples) They serve all sorts of essential functions: they act as signaling molecules, neurotransmitters, they act to facilitate the transport of molecules, they sometimes can act as antioxidants Some of these peptides are going to sound really familiar Some of the most important things that people have heard of like endorphins, insulin, GLP-1 (these are all peptide hormones) Some of these things can be produced synthetically So weβre able to create peptide-based therapies that can mimic the endogenous or body-produced peptide Again, Peter would say that the single most important of these would be insulin Insulin was discovered roughly 100 years ago It was clear that in a disease called type 1 diabetes, that people who lacked insulin because their beta cells were being attacked by their immune system were going to die, and if we couldnβt give them some form of insulin, that they were going to be in trouble Initially that was done by taking insulin from dogs or pigs But ultimately, once insulin could be synthetically produced, you could create a therapy to save the life of somebody with type 1 diabetes More recently, people will be very familiar with the GLP-1s Weβre going to talk about that because in the GLP-1 world, weβre not typically giving people the exact same peptide, but weβll come back to that A lot of times when people are asking about peptide supplements, theyβre not always referring to insulin or even GLP-1s What is the goal with peptides that you want to make sure we talk about today
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