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Rathkopf highlighted the early signal seen with I-DXd, a B7-H3–targeted ADC, noting a confirmed response rate of approximately 25 percent in the overall mCRPC cohort and a particularly notable 33% response rate among patients with liver metastases, a population typically associated with poor prognosis

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Re-expression of both ASS1 and ASL reduced the growth of ccRCC in vitro and in vivo in a catalytic-dependent manner by reducing the production of aspartate and increasing nitric oxide 165

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