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SCH-B significantly reduced TNF-α, IL-1β, INF-γ, and IL-6 concentrations and mRNA expression levels in colon tissue and inhibited phosphorylation of IκBα, NF-κB p65, p38 MAPK, c-Jun NH2-terminal kinase, and extracellular signal-regulated kinase in DSS-induced UC mice [477]

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Retatrutide is still being studied for potential cardiac side effects (increased heart rate)

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