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At the same time, plasma NO levels increased following RES administration ( Another study investigated whether RES reduces brain damage after I/R by suppressing inflammation mediated by the NLRP3 inflammasome and whether autophagy and the signaling protein Sirt1 are involved in this process.To examine these mechanisms, healthy male Sprague–Dawley rats were subjected to MCAO for 1 hour followed by 24 hours of reperfusion to induce cerebral I/R injury