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Introduction Parkinson's Disease is a neurodegenerative disease that usually develops late in life and is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc)

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Moreover, the MDD-related reductions in GABA are probably not related to impaired function in GABA synthesis via GAD, but instead it is more likely that these changes in GABA concentrations are related to pathology in calbindin-IR interneurons or in glia, although more data are required to confirm these ideas

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