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[Google Scholar] 37.Cook JA, Kim SY, Teague D, Krishna MC, Pacelli R, Mitchell JB, Vodovotz, Nims RW, Christodoulou D, Miles AM, Grisham MB, Wink DA

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Over time, irregular collagen organization and aberrant cross-linking increase tissue stiffness and perpetuate fibroblast activation through mechanical feedback mechanisms, contributing to progressive joint impairment (140, 141)