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Moreover, a randomized double-blind placebo-controlled clinical trial indicated that supplementation with Coenzyme Q10 (30 mg/day) and L-carnitine (500 mg/day) for 8 weeks had beneficial effects on migraine symptoms and serum levels of lactate (166)

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Turning to the evidence collected in in vivo models, rats fed a diet containing 3 g of Hcy per kg of diet for 2 weeks and subsequently supplemented with 8 mg of folic acid per kg of diet for 8 weeks, showed a significant containment of the increase in serum Hcy levels and an associated significant reduction in the incidence of vascular damage

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