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In addition, phytochemicals suppress the expression of endothelin-1 (ET-1), a potent vasoconstrictor, which further contributes to improved vascular tone and reduced coronary vasospasm (Carulli et al., 2025

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Indeed, H 1 receptor blockers have an established and valued place in the treatment of itching of allergic and non-allergic origin (Skidgel et al ., 2011)