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Even if we quibble with their concepts and definitions today, it is undeniable that the engineers spoke with a scientific authority accepted by their contemporary audience

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Dysregulation of NF-κB has been implicated in diverse inflammatory disorders such as rheumatoid arthritis, multiple sclerosis, asthma, and inflammatory bowel disease ( Regulation of NF-κB Signaling by the Wnt/β-Catenin Pathway Negative Regulation of NF-κB Signaling by Wnt/β-Catenin The first compelling evidence that Wnt/β-catenin negatively regulates NF-κB activity came from the observation that overexpressed β-catenin physically interacted with and inhibited NF-κB function in human colon and breast cancer cells (1)