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Tirzepatide is administered as a once-weekly subcutaneous injection, with dosing typically initiated at 2.5 mg and increased by 2.5 mg every 4 weeks up to a maintenance dose of 5-15 mg based on tolerability and therapeutic response

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FOXO4-DRI improves the testicular microenvironment in naturally aged mice FOXO4-DRI-treated aged testes showed decreased interstitial SA-β-gal activity (Figure 7A) as well as lower levels of senescence-associated proteins p53, p21, and p16 (Figure 7B–7E)