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Non-canonical pathways such as Mitogen activated protein kinases (MAPKs), Extracellular regulated Kinases (ERK1/2), and p-38, along with Jun N-terminal kinases (JNK), Src, phosphatidyl inositol 3 kinase (PI3Kinase)/AKT, Wnt/β-catenin/Ror2 signalling pathways, and NLRP3 inflammasome transduce the pro-fibrotic effects of TGF-β1 concluding to EMT and fibrosis as discussed below

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In patients with malignant tumors, ctDNA mainly consists of DNA from primary or metastatic tumor cells

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